R. vanzolinii, ranked as Least Concern on the Red List, inhabits areas of central Peru east of Rio Ucayali into Brazil. It has a wide range that also encompasses much of the lowlands southeast of Pucallpa. It is a terrestrial species of lowland tropical moist forests where it lives in tree holes, water-filled bromeliads and other phytotelmata.
This species is somewhat larger than other species is the vanzolinii genetic group. It is also one of the few uniformly spotted Ranitomeya species. The frog’s ground color is black and it has yellow dots evenly spread over the whole body, with exception of the front and hind limbs, which have an irregular greyish or bluish pattern.
Apparently, biparental care is usually present in this species, and pairs are often found living in very close proximity (often on the same plant).